Harnessing the Potential of Tocotrienol and Mixed-Carotene
by Bryan See - January 25, 2017
Despite 5,000 years of recorded human consumption, many people are still unclear about the benefits of palm oil. Palm trees produce fruit throughout the year for 20 to 25 years. They produce two types of oil—red palm oil from the flesh, and palm kernel oil from the seed of palm fruit. Red palm oil contains most of the health-promoting phytonutrients with a balanced fatty acid profile (approximately 50 percent saturated and 50 percent polyunsaturated) and can be used in food applications, while palm kernel oil is usually found in non-food applications. Most importantly, the oil palm (Elaeis guineensis) is considered a non-genetically modified organism (non-GMO).
The unique naturally occurring phytonutrients in red palm oil give it a different profile than vegetable oils such as soybean, canola, sunflower, etc. Red palm oil contains high levels of tocotrienols (super vitamin E) and mixed-carotenes. These phytonutrients are often referred to as the "crown jewels" of red palm oil. ExcelVite brands its palm phytonutrient ingredient full-spectrum tocotrienol complex as EVNol™ and EVNol SupraBio™, and the mixed-carotene is EVTene™. These branded tocotrienol and mixed-carotene complexes are clinically researched, offering a significant body of scientific support.
Increased awareness toward the burden and cost of contracting neurodegenerative diseases (such as Alzheimer’s disease)—as well as potential adverse effects associated with pharmaceutical agents for treatment of these conditions—are currently driving consumer demand for natural and clinically researched ingredients in brain/cognitive health supplements. Research about brain health support by EVNol SupraBio is extremely promising in pre- and post-stroke settings.
An ongoing human clinical trial (NUTRITION – Clinical Trial Identifier NCT015782629) is currently being conducted by researchers from the Ohio State University Medical Center on EVNol SupraBio for neuroprotection. Both the National Institutes of Health (NIH) and Malaysian Palm Oil Board have supported this nearly two decades of tocotrienol and neuroprotection research.
In the meantime, in a pre-stroke clinical setting, a group of researchers from University Science Malaysia conducted and published a double-blind and placebo-controlled human clinical trial in the prestigious American Heart Association’s journal Stroke. The research indicated daily supplementation of 400 mg of palm tocotrienol complex (as EVNol SupraBio) attenuated brain white matter lesion progression after two years of supplementation (Gopalan Y et al. 2014). Reports in medical journals have linked white matter lesions as an independent precursor to stroke (Yamauchi H et al. 2002) (Wong TY et al. 2002) (Vermeer SE et al. 2003) (Rost NS et al. 2010).
To date, at least 15 human studies conducted on EVNol or EVNol SupraBio have been published. These studies covered various conditions such as inside-out skin and hair benefits, cholesterol and heart health, immune support, liver health, and the attenuation of brain white matter lesion or brain health.
In addition to the bioefficacy illustrated by extensive human clinical studies, ExcelVite’s EVNol SupraBio offers high bioavailability and bioefficiency. Regarding bioavailability, SupraBio guarantees improved absorption of each of the tocotrienol isoforms by 250 to 300 percent (SupraBio system U.S. Patent 6,596,306). As for bioefficiency, a human tissue distribution study indicated the ingredient was able to deliver and deposit the tocotrienols in vital human organs and tissues (such as the brain, heart, liver, skin and adipose tissue) (Patel V et al. 2012).
The company’s other flagship product, EVTene mixed-carotene complex, primarily contains alpha-carotene and beta-carotene, along with some gamma-carotene and lycopene. It is naturally extracted and concentrated from red palm oil, with one of the highest alpha-carotene levels in the market. In addition, EVTene’s natural mixed-carotene composition is exactly the same as found in carrots.
EVTene alpha- and beta-carotene is known as natural pro-vitamin A, which is the essential vitamin to fight malnutrition and support night vision. Epidemiologic studies also reported supplementation of natural mixed-carotene complex with alpha-carotene and beta-carotene helped support healthy vision (AMD) (Wu J et al. 2015), elongation of telomeres (Min KB, Min JY. 2016), cardiovascular health (Ciccone MM et al. 2013) and healthy skin (Pezdirc K et al. 2016).
EVTene can also be used as a natural yellow-orange colorant in various food and beverage applications (e.g., drinks, ice cream, cheese). It is a true plant-based color to replace synthetic dyes (tartrazine and sunset yellow), as well as synthetic and non-plant beta-carotene.
Another differentiating attribute of ExcelVite is it was the first GMP (good manufacturing practice)-certified producer for tocotrienols and mixed-carotene in the world. The company’s Malaysian manufacturing facility has consecutively been current GMP-certified since 2007 and was inspected by FDA in 2012. In addition, its laboratory carries ISO/IEC 17025 accreditation and has been awarded the Laboratory Excellence Award for 10 consecutive years.
As a manufacturer of branded phyto-ingredients from red palm oil, ExcelVite is committed to sustainably source and only purchase crude palm oil from plantations located within Peninsular Malaysia. These plantations are on legally designated agricultural land that has been cultivated over three to four 25-year cycles with no sustainability issues.